Association between Dopamine Transporter (DAT1) Genotype, Left-Sided Inattention, and an Enhanced Response to Methylphenidate in Attention-Deficit Hyperactivity Disorder
نویسندگان
چکیده
منابع مشابه
Evidence of an association between 10/10 genotype of DAT1 and endophenotypes of attention deficit/hyperactivity disorder.
INTRODUCTION Genetic variance of attention deficit-hyperactivity disorder (ADHD) is a strong determinant of this disorder. The 40 base pairs (bp) variable number tandem repeat (VNTR) located in the 3' untranslated region (UTR) of DAT1 gene increases the expression of the dopamine transporter. Therefore, DAT1 has been associated with susceptibility to ADHD. OBJECTIVE To determine the associati...
متن کاملDopamine transporter in attention-deficit hyperactivity disorder normalizes after cessation of methylphenidate.
Attention-deficit hyperactivity disorder (ADHD) is a common neurodevelopmental disorder of childhood, which is frequently treated with methylphenidate. The short-term response to treatment with methylphenidate is a substantial decrease in dopamine transporter density, with improvement in neuropsychological tests. In this study, single-photon emission computed tomography was used to investigate ...
متن کاملUnaltered dopamine transporter availability in adult attention deficit hyperactivity disorder.
OBJECTIVE The authors examined whether patients with attention deficit hyperactivity disorder (ADHD) have altered striatal dopamine transporter levels, which may explain psychostimulant effects in this disorder. METHOD Single photon emission computed tomography and [(123)I]2beta-carbomethoxy-3beta-(4-iodophenyl)tropane ([(123)I]beta-CIT) were used to assess dopamine transporter availability i...
متن کاملMethylphenidate for Attention-Deficit/Hyperactivity Disorder.
know about the risks of the procedure. Do the benefits outweigh the risks? Jurors in states with the reasonablepatient standard can ask themselves, “Would I have wanted to know about this risk?” “Would it have affected my decision making?” Drs Drolet and Brower also express concerns about operationalizing the reasonable-patient standard. They argue that each patient’s informational needs are un...
متن کاملDopamine transporter genotype conveys familial risk of attention-deficit/hyperactivity disorder through striatal activation.
OBJECTIVE The dopamine transporter (DAT1) gene has been implicated in attention-deficit/hyperactivity disorder (ADHD), although the mechanism by which it exerts its effects remains unknown. The polymorphism associated with ADHD has been shown to affect expression of the transporter in vitro and in vivo. Dopamine transporters are predominantly expressed in the striatum, but also in the cerebella...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Neuropsychopharmacology
سال: 2005
ISSN: 0893-133X,1740-634X
DOI: 10.1038/sj.npp.1300839